Institute for Biomedical Engineering (IBE)

Office 609 Mechanical and Mechatronic Engineering

Banghoek Road

Stellenbosch University

Stellenbosch 7600,

Stellenbosch

(W): +27 21 808 9040

(C): + 27 72 388 0372

mnieuwoudt@sun.ac.za ; martin.nieuwoudt@gmail.com

2009: PhD with Honorary Academic Colours, Dept of Chemical Engineering, University of Pretoria: Bio-artificial Liver Support System: An evaluation of models used in demonstrating or improving metabolic and/or clinical efficacy. http://upetd.up.ac.za/thesis/available/etd-06112010-130329/

2001: Honours with Distinction, Bioengineering, University of Pretoria.

Subjects: Bioengineering,dvanced Literature Study (Nitric Oxide metabolism), Biosystems (UML-based neural synapse learning model),Biomaterials, Ergonomics

1994: Diploma in Nuclear Medicine Technology, Peninsula Technicon, Groote Schuur hospital, Cape Town, South Africa. Subjects: Clinical Nuclear Medicine, Applied Nuclear Medicine, Radiopharmacology

1992: Mathematics and Physics courses. University of South Africa (UNISA):

1989: BSc Degree, Stellenbosch University, Stellenbosch, South Africa.

Subjects: Physiology, Psychology, Biochemistry

Strategic Management, Damelin College, 2017

UNISA-WIPO Advanced Intellectual Property Management course, 2014

Agent Based Modeling, SACEMA, 2017

Bayesian Analysis of Longitudinal Studies, with Emmanuel Lessaffre, 2015, 2016

Quantitative Bias Analysis with Matt Fox, SACEMA, 2014

Bayesian Biostatistics, with Emanuel Lesaffre, 2013

Joint Modeling of repeated measures and survival outcomes in R, with Dimitris Rizopoulos, 2013

Biostatistics – Regression topics, SACEMA, 2013

Advanced Epidemiology with Matt Fox, SACEMA, 2012

Meaningful Modeling of Epidemiological data, AIMS, 2012, 2013

Joint Modeling course. International workshop on Statistical modeling, Charles University, Prague, Czech republic, 2012

Survival Analysis with Stata 12, University of Pretoria, 2011

Applied Epidemiology, University of Pretoria, 2011

Clinical Epidemiology, University of Pretoria, 2011

Bayesian Statistics and WinBUGS, NIHES, Rotterdam, 2010

Bayesian inference for biomedical data using WinBUGS, University of Pretoria, 2009

Repeated Measures data analysis with SAS 9.2 and Stata 11, University of Pretoria, 2009

Biomedical data analysis with Stata 11, University of Pretoria, 2009

Object-oriented design and analysis with the Unified modelling language (UML), 2007

Phylogenetics/Bioinformatics honours part time, University of Pretoria, 2008

Introduction to programming with C ++ and C #, Hatfield Business College, Pretoria, 2005

2014 (December) – current: Director, Stellenbosch University Institute for Biomedical Engineering (IBE).

Associate Professor – Dept of Mechanical and Mechatronic Engineering, Stellenbosch University.

Adjunct Professor of Biomedical Engineering at Northwestern University, Chicago, USA.

SA Program Director for Global Health Technologies (GHT) study abroad program with Northwestern University (Chicago).

 Establishment of the IBE, infrastructure building

 Project strategy, planning, management

 Financial stream identification and sourcing

 Research

 Student Supervision

 GHT Program development/management

2011– 2017: Researcher at DST/NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA) [full-time]. Basic responsibilities:

 New project identification

 Proposal writing

 Project management

 Student Supervision

 Data analysis and publication

2002 - 2011: Senior Researcher, Biotech Project Commercialization Fellow and Laboratory Manager for the Hepato-gastroenterology Research Unit, at the University of Pretoria, South Africa [full time]. Basic responsibilities:

 Implementation of novel in vitro and in vivo experimental methods

 Management of tissue engineering and molecular laboratory

 Staff management and training

 Proposal writing

 Animal/human ethics committee proposals

 Data analysis and publication

 Research funds management and reporting

 Project commercialization strategies

2001: Divers Alert Network (DAN). Researcher and Operations Manager.

Statistical research in dive accident and hyperbaric medicine treatment,

Training of medical and dive personnel in hyperbaric, O2 therapy and CPR.

1996-2000: Maritime and Diving industries in various countries:

Caribbean, Canada, England, Malta, Greece, Australia.

Employed as offshore yacht master and dive master,

training of divers, dive leadership and planning.

1995-1996: Muelmed Medical Centre Nuclear Medicine Technologist, Pretoria, South Africa [full time]. Extensive laboratory and clinical experience with research and diagnostic radio-isotopic studies and quality control.

1992-1994: Clinical Nuclear Medicine Technology in Groote Schuur Hospital, Cape Town, South Africa [full time]. Trained for diploma and worked in clinical and laboratory nuclear medicine technology.

1991: Business Management, Morkels retail, Cape Town, South Africa [full time].

1990: Movement and Martial Arts Instructor, Cape Town, South Africa [full time].

1985-1989: B.Sc degree at Stellenbosch University, Stellenbosch, South Africa [full time].

Frequentist and Bayesian Statistical modelling,

Physiological Systems Modelling,

Viral and Pharmaco-Kinetics

Tissue Engineering, Lab cell culturing techniques,

Small and large animal abdominal surgical techniques,

Molecular techniques, e.g. RNA, DNA isolation, RT-PCR etc

Gamma Radio-Isotopic Imaging,

Positron Emission Tomography,

Magnetic Resonance Tomography,

Computed Tomography

Scanning and Transmission Electron Microscopy

Fluorescence Photo-Microscopy,

Spectrophotometric Metabolite Detection Methods,

Gas and Liquid Chromatography Mass Spectrometry

Honorary Academic Colours awarded for PhD thesis 2009. Honours with distinction in Bioengineering 2002.

Award for Clinical Excellence, best presentation at the SA Gastroenterology Society congress, June, 2007.

Award for Clinical Excellence, best presentation at the SA Gastroenterology Society congress, April, 2003.

Overall winner of the S.H. Skaife Biology Competition: South Africa 1984. Pollinator-plant co-evolution in indigenous epiphytic orchids. Also the National winner of Young Scientists Competition: Zimbabwe 1981 on a subset of the same project

2018 – current: SU Strategic seed funding to establish Stellenbosch University Institute for Biomedical Engineering (IBE). Total R 3,65 M ZAR (awarded R 1 M per annum)

2016 - 2018: Co-Principal Investigator. Funding from the SA national Blood Donor Services (SANBS). For data analysis and publication of the effect of regular blood donation on iron stores and their potential depletion in healthy SANBS donors. R 200 K ZAR

2012 - 2017: Senior Researcher. DST/NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA) core internal funding. Salary + Travel.

2008 - 2011: Co-Principal Investigator. Norway-NRF fund for the development of an Integrated Health Information System for the Pretoria academic hospital HIV clinic. 600 K ZAR

2002 - 2011: Co-Principal Investigator. SERA and Innovation fund, South African National Research foundation (NRF), for the Bioartificial liver project. 12 million ZAR

2007 - 2008: Joint University of Pretoria and Council for Scientific and Industrial Research (CSIR) funding, for the Bioartificial liver project. 2 million ZAR

Sokoya T, Helen C. Steel HC, Nieuwoudt M, Rossouw TM. (2017) HIV as a Cause of Immune Activation and Immunosenescence. Mediators of Inflammation, Volume 2017, Article ID 6825493 https://doi.org/10.1155/2017/6825493

Gill Z, Nieuwoudt M, Ndifon W. (2017) The Hayflick Limit and Age-Related Adaptive Immune Deficiency. Gerontology. DOI: 10.1159/000478091

Sempa JB, Ujeneza EL, Nieuwoudt M. (2017) Systematic review of statistically-derived models of immunological response in HIV-infected adults on antiretroviral therapy in Sub-Saharan Africa. PLoS ONE 12(2): e0171658. DOI:10.1371/journal.pone.0171658

Rossouw TM, Nieuwoudt M, Manasa J, Malherbe G, Lessells RJ, Pillay S, Danaviah S, Mahasha P, van Dyk G, de Oliveira T. (2016) HIV Drug Resistance Levels in Adults Failing First Line Antiretroviral Therapy in Urban and Rural Settings in South Africa. HIV Medicine. DOI: 10.1111/hiv.12400.

Sempa JB, Dushoff J, Daniels MJ, Castelnuovo B, Kiragga AN, Nieuwoudt M, Bellan SE. (2016) Reevaluating Cumulative HIV-1 viral load as a Prognostic Predictor: Predicting Opportunistic Infection Incidence and Mortality in a Ugandan cohort. Am J of Epidemiol. DOI:10.1093/aje/kwv303

Lawrie D, Payne H, Nieuwoudt M. (2015) Glencross DK Observed full blood count and lymphocyte subset values in a cohort of clinically healthy South African children from a semi-informal settlement in Cape Town. South African Medical Journal (SAMJ). Sep 21;105(7):589-95. DOI: 10.7196/SAMJnew.7914

Nieuwoudt M, Lameris R, Corcoran C, Rossouw TM , Slavik T, Du Plessis J, Omoshoro-Jones JAO, Stivaktas PI, Van der Merwe SW. (2014) Polymerase chain reaction amplifying mycobacterial DNA from aspirates obtained by endoscopic ultrasound allows accurate diagnosis of mycobacterial disease

in HIV-positive patients with abdominal lymphadenopathy. Ultrasound in Med. & Biol., Vol. 40, No. 9, pp. 2031–2038

Wlodzimirow KA, Eslami S, Abu-Hanna A, Nieuwoudt M, Chamuleau RAFM. (2014) A systematic review on prognostic indicators of Acute Liver Failure and their predictive value for poor outcome. BJMMR, 4(15): 2796-2852.

Du Plessis J, Roos L, Slavik T, Stivaktas PI, Nieuwoudt M, Vieira W, Pretorius E, van Wyk SG, Beukes M, Van der Merwe SW. (2013) Activated intestinal macrophages in liver cirrhosis produce nitric oxide and release IL-6 that may disrupt intestinal barrier function. J Hepatol. Jun;58(6):1125-32.

Wlodzimirow K, Eslami S, Nieuwoudt M, Abu-Hanna A, Chamuleau R.A.F.M. (2012) Prediction of poor outcome in patients with acute liver failure - Systematic review of prediction models. PLOS ONE, 7(12): e50952. doi:10.1371/journal.pone.0050952

Wlodzimirow K, Eslami S, Nieuwoudt M, Abu-Hanna A, Chamuleau R.A.F.M. (2012) Acute liver failure: one disease, more than 40 definitions. Alimentary Pharmacology & Therapeutics, 35(11):1245–1256

Wlodzimirow K, Eslami S, Abu-Hanna A, Nieuwoudt M, Chamuleau R.A.F.M. (2012) Acute liver failure - what is it? Hepatology, 55( 4):1306–1307 Wlodzimirow KA, Eslami S, Abu-Hanna A, Nieuwoudt M, Chamuleau RAFM. (2012) A systematic review on prognostic indicators of acute on chronic liver failure and their predictive value for mortality. Liver International, doi: 10.1111/j.1478-3231.2012.02790.

Moodley Y, Linz B, Bond RP, Nieuwoudt M, Himla H, Schlebusch CM, Bernho S, Hale J, Suerbaum S, Mugisha L, van der Merwe SW, Achtman M. (2012) Age of the Association between Helicobacter pylori and Man, Plos Pathogens, 8(5): e1002693.

Veldsman C, Kock M, Rossouw T, Nieuwoudt M, Maeurer M, Hoosen A, Ehlers M. (2009) Quantiferon-TB gold ELISA assay for the detection of Mycobacterium tuberculosis-specific antigens in blood specimens of HIV-positive patients in a high-burden country. FEMS Immunol Med Microbiol 57:269-73.

Nieuwoudt M, Wiggett S, Sentle L, van der Merwe SW. Imaging glucose metabolism in perfluorocarbon-perfused hepatocyte bioreactors using positron emission tomography. Journal of Artificial Organs 2009;12:247-57.

Nieuwoudt M, Engelbrecht GHC, Sentle L, Auer R, Kahn D, van der Merwe SW. (2009) Non-toxicity of IV injected perfluorocarbon oxygen carrier in an animal model of liver regeneration following surgical injury. Artificial Cells, Blood substitutes, and Biotechnology 37:1-8.

Nieuwoudt M, Kunnike R, Smuts M, Becker J, Stegmann GF, Van der Walt C, Neser J, Van der Merwe S. (2006) Standardization criteria for an ischemic surgical model of acute hepatic failure in pigs. Biomaterials 27(20):3836-45.

van der Merwe SW, Conradie MM, Bond R, Olivier BJ, Fritz E, Nieuwoudt M, Delport R, Slavik T, EngelbrechtG, Kahn D, Shephard EG, Kotze MJ, de Villiers NP, Hough S. (2006) The effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting. W J Gastroenterol. 12(28):4504-4510.

Nieuwoudt M, Kreft E, Olivier B, Malfeld S, Vosloo J, Stegman F, Kunneke R, Van Wyk AJ, Van de Merwe SW. (2005) A Large Scale Automated Method for Hepatocyte Isolation: Effects on Proliferation in Culture. Cell Transplantation 14(5): 291-299.

Nieuwoudt M, Moolman S, Van Wyk AJ, Kreft E, Olivier B, Laurens JB, Stegman F, Vosloo J, Bond R, van der Merwe SW. (2005) Hepatocyte Function in a Radial-flow Bioreactor Using a Perfluorocarbon Oxygen Carrier. J Artificial Organs 29(11):915-918.

Nieuwoudt M (2014,2016) Organizer of and presenter at the SU Biomedical Engineering conferences of 2016 and 2014. “The Landscape of Bioengineering at Stellenbosch University and in Southern Africa”

Nieuwoudt M (2015) Invited presentation at the Sustainable Rural Health Research Days conference in Worcester South Africa 2015. “Bioengineering, Biostatistics and Epidemiology at Stellenbosch University”

Nieuwoudt M (2009) Invited speaker on, ‘The state of the art in Liver support therapy’, at the congress of the Hepatobiliary Association of Southern Africa, in Johannesburg, South Africa, October 2009.

Nieuwoudt M (2007) Invited key note speaker on ‘Hepatocyte based liver therapy’, at the New Key Opinion Leader (nKOL) congress of the Transplantation Society, in Cape Town, South Africa, November 15-18, 2007

van Rooyen R, Nieuwoudt M, Williams BG. Who test and When to treat: The impact of biomarker variation on decision-making regarding the initiation of ARV therapy. Poster 4093. Vancouver International Treatment as Prevention (TaSP) Workshop, April 22, 2013

Nieuwoudt M, Wiggett S, Sentle L, van der Merwe SW. Imaging glucose metabolism in perfluorocarbon-perfused hepatocyte bioreactors using positron emission tomography. Journal of Artificial Organs 2009;12:247-57.This was also presented at the World Federation of Nuclear Medicine and Biology congress in Cape Town, September 2010.

Nieuwoudt M, van der Merwe SW, Arazi A, Neumann AU, Song E. Viral Kinetics of Hepatitis C Virus genotype 5 in South African patients treated with Pegylated-Interferon-alfa and Ribavirin. Presentation at the SA Gastroenterology Society Congress 2007.

Nieuwoudt M, Moolman FS, Van Wyk AJ, Kreft E, Olivier B, Stegman GF, Vosloo J, Bond R, van der Merwe SW. An in vitro study of hepatocyte metabolic activity in the UP-CSIR high cell density, radial-flow bioreactor in the presence of a perfluorocarbon O2 carrier. Presentation at the SA Gastroenterology Society Congress 2004.

Nieuwoudt M, Kreft E, Olivier B, Malfeld S, Moolman S, Van Wyk AJ, van der Merwe SW. The metabolic evaluation of a novel Bioartificial Liver Support System. Presentation at the SA Gastroenterology Society Congress 2003.

Teaching and Post graduate supervision

Presentation of the Mechatronics 424 Statistics course to 180 students in January 2018

I also taught Biostatistics and Epidemiology at the University of Pretoria (in 2011)

Supervisor: Sempa J, Stellenbosch University: Statistical modeling of treatment outcomes in a Ugandan cohort of HIV(+)patients on HAART. PhD awarded in Clinical Epidemiology. 2017.

Co-supervisor with Wilfred Ndifon: Ujeneza E, Stellenbosch University. Mathematical modeling of long term Immune outcomes in HIV(+) patients on HAART in Southern African. Current PhD in Mathematics

Co-supervisor with Wilfred Ndifon: Gershom B, AIMS Stellenbosch University. Development of algorithms to quantify telomere length as a marker of Immune aging. Current PhD in Mathematics

Co-supervisor with Gert van Zyl: Sadie W, Dept of Virology. Development of a pre-analytical single-cell isolation HIV viral concentration product. Current PhD in Molecular Engineering

Co-supervisor with Cang Hui: Using Species Distribution Models for Spatial Conservation Planning of African Penguins, MSc Biomaths, Stellenbosch University. 2017

Co-supervisor with Thomas Niesler: van Zyl, F, Modeling the telemetry properties of an implantable device for Rhinoceros location and health monitoring. Current MEng. 2017

Co-supervisor with Theresa Roussouw: Sokoya T, University of Pretoria: Cotrimoxazole treatment of Immune Activation in HIV-infected patients on HAART. Current PhD in Clinical Epidemiology

Supervisor: Bicko S, Stellenbosch University: Model-based continuous age-related reference range estimation for biomarker data. MSc Mathematics with Distinction 2017.

Supervisor: Paganga M, African Institute for Mathematical Sciences (AIMS), Stellenbosch University: The association of viral fitness with drug resistance mutations in ARV treatment. AIMS Masters 2016.

Co-supervisor with Chris Aldrich and Petrus de Vries: Huenis T, Stellenbosch University. Early Detection of Risk of Autism Spectrum Disorder based on Recurrence Quantification Analysis of Electroencephalographic Signals. PhD Biomedical Engineering, 2015.

Supervisor: Bicko S, African Institute for Mathematical Sciences (AIMS), Stellenbosch University: Establishing appropriate models for age-related changes in lymphocyte cell markers in paediatric data from South Africa. AIMS Masters 2015.

Co-supervisor with Ameen Abu Hanna: Wlodzimorow K. Amsterdam Medical College, the Netherlands. Prognostic modeling for acute liver failure. PhD 2012.

Co-supervisor with Theresa Roussouw: Sokoya T, University of the Witwatersrand: Occurrence and Determinants Of Treatment Failure In Antiretroviral Therapy At Tshwane District Hospital. MSc Pharmocology, Wits University. Completed 2011.

Co-supervisor with Theresa Roussouw: Ozah EC, University of Pretoria. Bio-Psycho-Social Determinants Of Non-Adherence To Antiretroviral Treatment Among Hiv-Infected Patients At Tshwane District Hospital, Pretoria. M in Public Health, Completed 2011.

Co-supervisor with Theresa Roussouw: Membo K, University Of Pretoria. A Study Of The Clinical, Dem Establishing appropriate models for age-related changes in lymphocyte cell markers in paediatric data from South Africaographic And Referral Profiles Of Patients Attending The Witbank Hospital Wellness Clinic. M in Public Health, completed with distinction 2010.

Co-supervisor with Schalk van der Merwe: Lameris R. Free University of Amsterdam. Endoscopic ultrasound in HIV lymphadenopathy. Research project towards MBChB, Free University of Amsterdam, the Netherlands, 2011.

Co-supervisor with Schalk van der Merwe: Johannie du Plessis, University of Pretoria. Bacterial Translocation: Cause of activated intestinal macrophages in decompensated liver disease. MSc Immunology, 2011.

Co-supervisor with Schalk van der Merwe: De Groot R. Amsterdam Medical College. A comparison of metabolic efficacy of hepatocyte bioreactors with and without a PFC artificial oxygen carrier. Research project towards MBChB, Feree University of Amsterdam, the Netherlands, 2008.​